克罗米酚对异性恋低促性腺素性功能减退症有效

纽约（伦敦证券交易所社健康版）1月初四日报道：据发表在12月初出版的《生育与不育》杂志的一项统计数据认为克罗米衍生物对大部分较高促性腺素性功能与日俱增的男性症状有利。来自阿伯丁阿拉巴马大学的该统计数据的第一作者Scott J. Whitten教授在接受伦敦证券交易所通讯社受访时说：“原发性或获得性HH症状在接受危害性更大和更为昂贵的疗法（例如麻醉促性腺激素类）年前进行4个月初的克罗米衍生物了了疗法是有利的。”Whitten教授和老友研究者了克罗米衍生物对10名HH男性症状（HH是导致男性不育的少见状况）是否必要。统计数据称克罗米衍生物疗法1年后，4名卡尔曼(其族)综合征症状中会只有一名症状的精子剂量增加而全脑垂体功能与日俱增症症状的精子缺失症状仅不会得到改善。也就是说，该统计数据认为3名孩童发病的原发性HH男性症状经过3个月初克罗米衍生物的疗法精子剂量有了明显增加。目年前为止该组症状已有两名恢复了生殖。Whitten教授说：“除非对克罗米衍生物疗法不会加成，我们不会因为副作用停止对症状使用该药物。”最终作者总结说：“因为情况下有限，对HH症状促性腺激素类药物和克罗米衍生物的随机研究者很难进行，然而利用多系列的严苛选择标准对症状进行评定可能帮助进一步验证克罗米衍生物恢复男性较高生殖的实证。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色宿命

编辑： 张靖